Endocrine Abstracts

Background: Anti-Müllerian hormone (AMH) is a key regulator of preantral follicle development. In human polycystic ovarian syndrome (PCOS) hyperandrogenism drives antral follicle excess, and is associated with elevated AMH levels. It is currently unknown if androgens regulate AMH secretion.Objective and hypothesis: To provide insights into the regulation of AMH action, we hypothesized that dihydrotestosterone (DHT), the most potent androgen, stimula...

Introduction: The importance of vitamin D beyond bone health is increasingly recognised. As a result Ireland has recently introduced a policy of vitamin D supplementation for all infants. A vitamin D level of 50 nmol/l for children/adolescents has been recommended as sufficient (1). We sought to establish the vitamin D status in children and adolescents attending a Paediatric Endocrinology Department and explore the relationship between vitamin D status and age, sex, body mass...

The advances in cancer therapy over the past two decades have led to remarkable improvements in survival rates, but treatments such as chemotherapy, radiotherapy and/or surgery can induce premature ovarian insufficiency (POI) in some circumstances. Fertility preservation (FP) is therefore a key challenge for these women. At diagnosis, all women affected by cancer should benefit from an informed consultation on the threat of compromising their fertility with planned cancer trea...

40year old bodybuilder was re-referred to clinic with low mood, reduced libido, poor morning erections and fatigue. His past medical history included hypogonadal hypogonadism secondary to anabolic androgen abuse, mental health disease and personality disorders. He had undergone breast reconstruction surgery for bilateral gynaecomastia secondary to anabolic steroid use despite taking precautionary tamoxifen injections as per peer groups’ advice. Previously, he was lost for...

Introduction: Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy and accounts for 25% of all childhood cancer. With dramatically improved survival rates the long term treatment complications are very important. ALL patients treated with cranial radiotherapy (CRT) and chemotherapy are at increased risk of GH deficiency (GHD), hyperparathyroidism, thyroid cancer and meningiomas.Method: We present a 45-year-old woman diagnosed with ...

A 43-year-old African lady initially presented in September 2007 with hypothyroidism (fT4 0.6 ng/dl (0.8–2.0) and TSH 110 mU/l (0.3–4.00)). She gave a history of pain in the neck with transient symptoms of thyrotoxicosis. It was felt that she had gone hypothyroid following an episode of subacute thyroiditis and was started on L-thyroxine. Her compliance was questioned as her TSH fluctuated from being high to being suppressed on 25 μg of...

Hyperthyroidism in Graves’ disease (GD) is caused by thyroid-stimulating autoantibodies to the TSH receptor. Hypothyroidism in Hashimoto’s thyroiditis (HT) is associated with thyroid peroxidase and thyroglobulin autoantibodies. Transformation of HT to GD has been rarely reported. We report a woman with history of HT, who then developed GD.Case presentation: A 50-year-old female with a past history of hypothyroidism due to HT treated with Levo...

Introduction and aims: Women with polycystic ovary syndrome (PCOS) are at significantly increased risk of developing impaired glucose tolerance (IGT; prevalence 9–35%) and type 2 diabetes (T2DM; prevalence 2–10%), hence screening for these complications is recommended. The American Androgen Excess Society (AAES) recommends a biannual oral glucose tolerance test (OGTT) in all women with PCOS but this is costly and inconvenient. Alternative strategies which minimise th...

Background: Adult craniopharyngioma (CP) patients without GH therapy exhibit high risk for cardiovascular disease (CVD) and mortality with a higher risk in women than in men. Approximately 50% of children treated for CP are obese at follow-up and hypothalamic damage seems to be a major cause. In GHD CP children GH treatment improves linear growth but does not ameliorate weight gain, but the impact of long-term GH therapy into adulthood is presently unknown.<p class="abstex...

Survivors of childhood (CO) ALL treated with prophylactic cranial radiotherapy (CRT) often exhibit (GHD) and increased cardiovascular risk. The aim of this study was to evaluate the effect of 4 years of GH therapy on cardiovascular risk factors in 16 former ALL patients and to compare them with matched population controls after 4 years.Sixteen former CO ALL patients (women=8), aged 24–37 years, treated with CRT (18–24 Gy) and chemotherapy with ...